anxiety disorder

Anxiety disorder is a blanket term covering several different forms of abnormal and pathological fears and anxieties which only came under the aegis of psychiatry at the very end of the 19th century. Current psychiatric diagnostic criteria recognize a wide variety of anxiety disorders. Recent surveys have found that as many as 18% of Americans may be affected by one or more of them.

diagnosis

Anxiety disorders are often debilitating chronic conditions, which can be present from an early age or begin suddenly after a triggering event. They are prone to flare up at times of high stress and are frequently accompanied by physiological symptoms such as headache, sweating, muscle spasms, palpitations, and hypertension, which in some cases lead to fatigue or even exhaustion.

Although in casual discourse the words anxiety and fear are often used interchangeably, in clinical usage, they have distinct meanings; anxiety is defined as an unpleasant emotional state for which the cause is either not readily identified or perceived to be uncontrollable or unavoidable, whereas fear is an emotional and physiological response to a recognized external threat. The term anxiety disorder, however, includes fears as well as anxieties. Indeed, phobias (fears which are "persistent or irrational") constitute the majority of anxiety disorder cases.

Anxiety disorders are often comorbid with other mental disorders, particularly clinical depression, which may occur in as many as 60% of people with anxiety disorders. The fact that there is considerable overlap between symptoms of anxiety and depression, and that the same environmental triggers can provoke symptoms in either condition, may help to explain this high rate of comorbidity.

Studies have also indicated that anxiety disorders are more likely among those with family history of anxiety disorders, especially certain types.

Sexual dysfunction also often accompanies anxiety disorders, although it is difficult to determine whether anxiety causes the sexual dysfunction, or whether they arise from a common cause. The most common manifestations in individuals with anxiety disorder are avoidance of intercourse, premature ejaculation or erectile dysfunction among men and pain during intercourse among women. Sexual dysfunction is particularly common among people affected by panic disorder (who may fear that a panic attack will occur during sexual arousal) and posttraumatic stress disorder.

causes and contributing factors

Clinical and animal studies suggest a correlation between anxiety disorders and difficulty in maintaining balance. A possible mechanism is malfunction in the parabrachial nucleus, a brain structure that, among other functions, coordinates signals from the amygdala with input concerning balance. The amygdala is involved in the emotion of fear.

Especially the basolateral amygdala has been implicated in anxiety generation. A relationship between anxiety and dendritic arborization of the amygdaloid neurons is well known. SK2 potassium channels mediate inhibitory influence on action potentials and reduce arborization. By overexpressing SK2 in the basolateral amygdala, anxiety was reduced and stress-induced corticosterone secretion at a systemic level decreased in an animal model. Mutations in related SK3 are suspected to be a possible underlying cause for several neurological disorders, including anxiety.

Additionally, low levels of GABA, a neurotransmitter that reduces activity in the central nervous system, contribute to anxiety. A number of anxiolytics achieve their effect by modulating the GABA receptors.

Selective serotonin reuptake inhibitors, the drugs most commonly used to treat depression, are also frequently considered as a first line treatment for anxiety disorders. A recent study using functional brain imaging techniques suggests that the effects of SSRIs in alleviating anxiety may result from a direct action on GABA neurons rather than as a secondary consequence of mood improvement.

Severe anxiety and depression are commonly induced by sustained alcohol abuse which in most cases abates with prolonged abstinence. Even moderate, sustained alcohol use may increase anxiety and depression levels in some individuals. Caffeine, alcohol and benzodiazepines can worsen or cause anxiety and panic attacks. In one study in 1988–1990, illness in approximately half of patients attending mental health services at one British hospital psychiatric clinic, for conditions including anxiety disorders such as panic disorder or social phobia, was determined to be the result of alcohol or benzodiazepine dependence. In these patients, cessation of their anxiety symptoms corresponded with stopping the use of the benzodiazepine or alcohol.

Intoxication from stimulants is likely to be associated with repetitive panic attacks.

There is evidence that chronic exposure to organic solvents in the work environment can be associated with anxiety disorders. Painting, varnishing and carpet laying are some of the jobs in which significant exposure to organic solvents may occur.

Later in life, anxiety disorder can arise in response to life stresses such as financial worries or chronic physical illness. Somewhere between 4% and 10% of older adults are diagnosed with anxiety disorder, a figure which is probably an underestimate due to the tendency of adults to minimize psychiatric problems or to focus on their physical manifestations. Anxiety is also common among older people who have dementia. On the other hand, anxiety disorder is sometimes misdiagnosed among older adults when doctors misinterpret symptoms of a physical ailment (for instance, racing heartbeat due to cardiac arrhythmia) as signs of anxiety.

types

generalized anxiety disorder

Generalized anxiety disorder is a common chronic disorder characterized by long-lasting anxiety that is not focused on any one object or situation. Those suffering from generalized anxiety experience non-specific persistent fear and worry and become overly concerned with everyday matters. Generalized anxiety disorder is the most common anxiety disorder to affect older adults.

panic disorder

In panic disorder, a person suffers from brief attacks of intense terror and apprehension, often marked by trembling, shaking, confusion, dizziness, nausea, difficulty breathing. These panic attacks, defined by the APA as fear or discomfort that abruptly arises and peaks in less than ten minutes, can last for several hours and can be triggered by stress, fear, or even exercise; although the specific cause is not always apparent.

In addition to recurrent unexpected panic attacks, a diagnosis of panic disorder also requires that said attacks have chronic consequences: either worry over the attacks' potential implications, persistent fear of future attacks, or significant changes in behavior related to the attacks. Accordingly, those suffering from panic disorder experience symptoms even outside of specific panic episodes. Often, normal changes in heartbeat are noticed by a panic sufferer, leading them to think something is wrong with their heart or they are about to have another panic attack. In some cases, a heightened awareness (hypervigilance) of body functioning occurs during panic attacks, wherein any perceived physiological change is interpreted as a possible life threatening illness (i.e. extreme hypochondriasis) .

phobias

The single largest category of anxiety disorders is that of Phobia, which includes all cases in which fear and anxiety is triggered by a specific stimulus or situation. Sufferers typically anticipate terrifying consequences from encountering the object of their fear, which can be anything from an animal to a location to a bodily fluid.

a) agoraphobia

Agoraphobia is the specific anxiety about being in a place or situation where escape is difficult or embarrassing. Agoraphobia is strongly linked with panic disorder and is often precipitated by the fear of having a panic attack. A common manifestation involves needing to be in constant view of a door or other escape route. In addition to the fears themselves, the term agoraphobia is often used to refer to avoidance behaviors that sufferers often develop. For example, following a panic attack while driving, someone suffering from agoraphobia may develop anxiety over driving and will therefore avoid driving in the future. These avoidance behaviors can often have serious consequences; in severe cases, one can even be confined to one's home.

b) social anxiety disorder

Social anxiety disorder (also known as social phobia) describes an intense fear of negative public scrutiny or of public embarrassment or humiliation. This fear can be specific to particular social situations (such as public speaking) or, more typically, is experienced in most (or all) social interactions. Social anxiety often manifests specific physical symptoms, including blushing, sweating, and difficulty speaking. Like with all phobic disorders, those suffering from social anxiety will attempt to avoid the source of their anxiety; in the case of social anxiety this is particularly problematic, and in severe cases can lead to complete social isolation.

c) obsessive-compulsive disorder

Obsessive compulsive disorder is a type of anxiety disorder primarily characterized by repetitive obsessions (distressing, persistent, and intrusive thoughts or images) and compulsions (urges to perform specific acts or rituals). The OCD thought pattern may be likened to superstitions insofar as it involves a belief in a causative relationship where, in reality, one does not exist. Often the process is entirely illogical; for example, the compulsion of walking in a certain pattern may be employed to alleviate the obsession of impending harm. And in many cases, the compulsion is entirely inexplicable, simply an urge to complete a ritual triggered by nervousness.

In a minority of cases, sufferers of OCD may only experience obsessions, with no overt compulsions; a much smaller number of sufferers experience only compulsions.

d) post-traumatic stress disorder

Post-traumatic stress disorder or PTSD is an anxiety disorder which results from a traumatic experience. Post-traumatic stress can result from an extreme situation, such as combat, rape, hostage situations, or even serious accident. It can also result from long term (chronic) exposure to a severe stressor, for example soldiers who endure individual battles but cannot cope with continuous combat. Common symptoms include flashbacks, avoidant behaviors, and depression.

e) seperation anxiety

Separation anxiety disorder is the feeling of excessive and inappropriate levels of anxiety over being separated from a person or place. Separation anxiety itself is a normal part of development in babies or children, and it is only when this feeling is excessive or inappropriate that it can be considered a disorder. Separation anxiety disorder affects roughly 7% of adults and 4% of children, but the childhood cases tend to be more severe, in some instances even a brief separation can produce panic.

treatment

Treatment options available include lifestyle changes; psychotherapy, especially cognitive behavioral therapy; and pharmaceutical therapy. Education, reassurance and some form of cognitive-behavioral therapy should almost always be used in treatment.

When medication is indicated SSRIs, such as fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil) and escitalopram (Lexapro) are generally recommended as first line agents. SNRIs such as venlafaxine (Effexor) are also effective. Benzodiazepines, such as alprazolam (Xanax), clonazepam (Klonopin) and diazepam (Valium) are also sometimes indicated for short-term or PRN use. They are usually considered as a second line treatment due to disadvantages such as cognitive impairment and due to their risks of dependence and withdrawal problems. Other medications commonly prescribed for anxiety disorders include GABA analogues such as gabapentin (Neurontin) or pregabalin (Lyrica), MAOIs such as phenelzine (Nardil) or tranylcypromine (Parnate), as well as the novel antidepressant mirtazapine (Remeron). TCAs such as imipramine, as well as atypical antipsychotics such as quetiapine, and piperazines such as hydroxyzine are also occasionally prescribed.

These medications need to be used with extreme care among older adults, who are more likely to suffer side effects because of coexisting physical disorders. Adherence problems are more likely among elderly patients, who may have difficulty understanding, seeing, or remembering instructions.

Treatment controversy arises because while some studies indicate that a combination of medication and psychotherapy can be more effective than either one alone; others suggest pharmacological interventions are largely palliative, and can actually interfere with the mechanisms of successful therapy. Meta-analysis indicates that psychotherapeutic interventions have superior long-term efficacy when compared to pharmacotherapy. However, the right treatment may very much depend on the individual patient's genetics and environmental factors.

Regular aerobic exercise, improving sleep hygiene and reducing caffeine are often useful in treating anxiety.

samgyetang

Samgyetang (Korean pronunciation: [samɡjetʰaŋ]) is a variety of guk or Korean soup, which primarily consists of a whole young chicken and Korean ginseng. The dish's name literally translates as "'ginseng chicken soup" in English. Samgyetang is traditionally served in the summer for its supposed nutrients, which replaces those lost through excessive sweating and physical exertion during the hot summers in Korea.

preparation and serving

To make samgyetang, a whole young chicken is stuffed with glutinous rice and boiled in a broth of Korean ginseng, dried seeded jujube fruits, garlic, and ginger. Depending on the recipe, other medicinal herbs such as wolfberry (gugija), Codonopsis pilosula (dangsam), and Angelica sinensis (danggwi) may also be added.

Like chicken soup, which is thought to help common sicknesses in the West, it is widely believed in Korea that samgyetang can both cure and prevent physical ailments. Proteins, minerals, and hormones from the whole chicken mixed with the beneficial properties of the ingredients combined in the dish makes it a revered culinary item in South Korea. Only whole uncut ingredients are used for the dish, as they are believed to preserve the maximum amount of nutrients.

Many Koreans enjoy it on three specific days in summer: "Chobok," "Jungbok," and "Malbok," which Koreans believe to be the hottest and most sultry of the year.

Specialty restaurants common in Korea serve nothing but samgyetang, having gained local popularity through their special recipe for the dish which are often kept secret. The dish is usually accompanied by side dishes and, in some restaurants, a small complimentary bottle of insamju (ginseng wine) is included.

internet

The Internet is a global system of interconnected computer networks that use the standardized Internet Protocol Suite (TCP/IP) to serve billions of users worldwide. It is a network of networks that consists of millions of private and public, academic, business, and government networks of local to global scope that are linked by copper wires, fiber-optic cables, wireless connections, and other technologies. The Internet carries a vast array of information resources and services, most notably the inter-linked hypertext documents of the World Wide Web (WWW) and the infrastructure to support electronic mail. In addition it supports popular services such as online chat, file transfer and file sharing, gaming, commerce, social networking, publishing, video on demand, and teleconferencing and telecommunications. Voice over Internet Protocol (VoIP) applications allow person-to-person communication via voice and video.

The origins of the Internet reach back to the 1960s when the United States funded research projects of its military agencies to build robust, fault-tolerant and distributed computer networks. This research and a period of civilian funding of a new U.S. backbone by the National Science Foundation spawned worldwide participation in the development of new networking technologies and led to the commercialization of an international network in the mid 1990s, and resulted in the following popularization of countless applications in virtually every aspect of modern human life. As of 2009, an estimated quarter of Earth's population uses the services of the Internet.

terminology

The terms Internet and World Wide Web are often used in everyday speech without much distinction. However, the Internet and the World Wide Web are not one and the same. The Internet is a global data communications system. It is a hardware and software infrastructure that provides connectivity between computers. In contrast, the Web is one of the services communicated via the Internet. It is a collection of interconnected documents and other resources, linked by hyperlinks and URLs. The term the Internet, when referring to the Internet, has traditionally been treated as a proper noun and written with an initial capital letter. There is a trend to regard it as a generic term or common noun and thus write it as "the internet", without the capital.

history

The USSR's launch of Sputnik spurred the United States to create the Advanced Research Projects Agency, known as ARPA, in February 1958 to regain a technological lead. ARPA created the Information Processing Technology Office (IPTO) to further the research of the Semi Automatic Ground Environment (SAGE) program, which had networked country-wide radar systems together for the first time. J. C. R. Licklider was selected to head the IPTO. Licklider moved from the Psycho-Acoustic Laboratory at Harvard University to MIT in 1950, after becoming interested in information technology. At MIT, he served on a committee that established Lincoln Laboratory and worked on the SAGE project. In 1957 he became a Vice President at BBN, where he bought the first production PDP-1 computer and conducted the first public demonstration of time-sharing.

At the IPTO, Licklider got Lawrence Roberts to start a project to make a network, and Roberts based the technology on the work of Paul Baran, who had written an exhaustive study for the United States Air Force that recommended packet switching (opposed to circuit switching) to achieve better network robustness and disaster survivability. UCLA professor Leonard Kleinrock had provided the theoretical foundations for packet networks in 1962, and later, in the 1970s, for hierarchical routing, concepts which have been the underpinning of the development towards today's Internet.

After much work, the first two nodes of what would become the ARPANET were interconnected between UCLA's School of Engineering and Applied Science and SRI International (SRI) in Menlo Park, California, on October 29, 1969. The ARPANET was one of the "eve" networks of today's Internet. Following on from the demonstration that packet switching worked on the ARPANET, the British Post Office, Telenet, DATAPAC and TRANSPAC collaborated to create the first international packet-switched network service. In the UK, this was referred to as the International Packet Switched Service (IPSS), in 1978. The collection of X.25-based networks grew from Europe and the US to cover Canada, Hong Kong and Australia by 1981. The X.25 packet switching standard was developed in the CCITT (now called ITU-T) around 1976.

X.25 was independent of the TCP/IP protocols that arose from the experimental work of DARPA on the ARPANET, Packet Radio Net and Packet Satellite Net during the same time period. Vinton Cerf and Robert Kahn developed the first description of the TCP protocols during 1973 and published a paper on the subject in May 1974. Use of the term "Internet" to describe a single global TCP/IP network originated in December 1974 with the publication of RFC 675, the first full specification of TCP that was written by Vinton Cerf, Yogen Dalal and Carl Sunshine, then at Stanford University. During the next nine years, work proceeded to refine the protocols and to implement them on a wide range of operating systems. The first TCP/IP-based wide-area network was operational by January 1, 1983 when all hosts on the ARPANET were switched over from the older NCP protocols. In 1985, the United States' National Science Foundation (NSF) commissioned the construction of the NSFNET, a university 56 kilobit/second network backbone using computers called "fuzzballs" by their inventor, David L. Mills. The following year, NSF sponsored the conversion to a higher-speed 1.5 megabit/second network. A key decision to use the DARPA TCP/IP protocols was made by Dennis Jennings, then in charge of the Supercomputer program at NSF.

The opening of the network to commercial interests began in 1988. The US Federal Networking Council approved the interconnection of the NSFNET to the commercial MCI Mail system in that year and the link was made in the summer of 1989. Other commercial electronic e-mail services were soon connected, including OnTyme, Telemail and Compuserve. In that same year, three commercial Internet service providers (ISPs) were created: UUNET, PSINet and CERFNET. Important, separate networks that offered gateways into, then later merged with, the Internet include Usenet and BITNET. Various other commercial and educational networks, such as Telenet, Tymnet, Compuserve and JANET were interconnected with the growing Internet. Telenet (later called Sprintnet) was a large privately funded national computer network with free dial-up access in cities throughout the U.S. that had been in operation since the 1970s. This network was eventually interconnected with the others in the 1980s as the TCP/IP protocol became increasingly popular. The ability of TCP/IP to work over virtually any pre-existing communication networks allowed for a great ease of growth, although the rapid growth of the Internet was due primarily to the availability of an array of standardized commercial routers from many companies, the availability of commercial Ethernet equipment for local-area networking, and the widespread implementation and rigorous standardization of TCP/IP on UNIX and virtually every other common operating system.

Although the basic applications and guidelines that make the Internet possible had existed for almost two decades, the network did not gain a public face until the 1990s. On 6 August 1991, CERN, a pan European organisation for particle research, publicized the new World Wide Web project. The Web was invented by English scientist Tim Berners-Lee in 1989. An early popular web browser was ViolaWWW, patterned after HyperCard and built using the X Window System. It was eventually replaced in popularity by the Mosaic web browser. In 1993, the National Center for Supercomputing Applications at the University of Illinois released version 1.0 of Mosaic, and by late 1994 there was growing public interest in the previously academic, technical Internet. By 1996 usage of the word Internet had become commonplace, and consequently, so had its use as a synecdoche in reference to the World Wide Web.

Meanwhile, over the course of the decade, the Internet successfully accommodated the majority of previously existing public computer networks (although some networks, such as FidoNet, have remained separate). During the 1990s, it was estimated that the Internet grew by 100 percent per year, with a brief period of explosive growth in 1996 and 1997. This growth is often attributed to the lack of central administration, which allows organic growth of the network, as well as the non-proprietary open nature of the Internet protocols, which encourages vendor interoperability and prevents any one company from exerting too much control over the network. Using various statistics, Advanced Micro Devices estimated the population of Internet users to be 1.5 billion as of January 2009.

technology

protocols

The complex communications infrastructure of the Internet consists of its hardware components and a system of software layers that control various aspects of the architecture. While the hardware can often be used to support other software systems, it is the design and the rigorous standardization process of the software architecture that characterizes the Internet and provides the foundation for its scalability and success. The responsibility for the architectural design of the Internet software systems has been delegated to the Internet Engineering Task Force (IETF). The IETF conducts standard-setting work groups, open to any individual, about the various aspects of Internet architecture. Resulting discussions and final standards are published in a series of publications, called Request for Comments (RFCs), freely available on the IETF web site. The principal methods of networking that enable the Internet are contained in specially designated RFCs that constitute the Internet Standards.

These standards describe a framework known as the Internet Protocol Suite. This is a model architecture that divides methods into a layered system of protocols (RFC 1122, RFC 1123). The layers correspond to the environment or scope in which their services operate. At the top is the Application Layer, the space for the application-specific networking methods used in software applications, e.g., a web browser program. Below this top layer, the Transport Layer connects applications on different hosts via the network (e.g., client-server model) with appropriate data exchange methods. Underlying these layers are the core networking technologies, consisting of two layers. The Internet Layer enables computers to identify and locate each other via Internet Protocol (IP) addresses, and allows them to connect to one-another via intermediate (transit) networks. Lastly, at the bottom of the architecture, is a software layer, the Link Layer, that provides connectivity between hosts on the same local network link, such as a local area network (LAN) or a dial-up connection. The model, also known as TCP/IP, is designed to be independent of the underlying hardware which the model therefore does not concern itself with in any detail. Other models have been developed, such as the Open Systems Interconnection (OSI) model, but they are not compatible in the details of description, nor implementation, but many similarities exist and the TCP/IP protocols are usually included in the discussion of OSI networking.

The most prominent component of the Internet model is the Internet Protocol (IP) which provides addressing systems (IP addresses) for computers on the Internet. IP enables internetworking and essentially establishes the Internet itself. IP Version 4 (IPv4) is the initial version used on the first generation of the today's Internet and is still in dominant use. It was designed to address up to ~4.3 billion Internet hosts. However, the explosive growth of the Internet has led to IPv4 address exhaustion which is estimated to enter its final stage in approximately 2011. A new protocol version, IPv6, was developed in the mid 1990s which provides vastly larger addressing capabilities and more efficient routing of Internet traffic. IPv6 is currently in commercial deployment phase around the world and Internet address registries (RIRs) have begun to urge all resource managers to plan rapid adoption and conversion.

IPv6 is not interoperable with IPv4. It essentially establishes a "parallel" version of the Internet not directly accessible with IPv4 software. This means software upgrades or translator facilities are necessary for every networking device that needs to communicate on the IPv6 Internet. Most modern computer operating systems are already converted to operate with both versions of the Internet Protocol. Network infrastructures, however, are still lagging in this development. Aside from the complex physical connections that make up its infrastructure, the Internet is facilitated by bi- or multi-lateral commercial contracts (e.g., peering agreements), and by technical specifications or protocols that describe how to exchange data over the network. Indeed, the Internet is defined by its interconnections and routing policies.

Structure

The Internet structure and its usage characteristics have been studied extensively. It has been determined that both the Internet IP routing structure and hypertext links of the World Wide Web are examples of scale-free networks. Similar to the way the commercial Internet providers connect via Internet exchange points, research networks tend to interconnect into large subnetworks such as GEANT, GLORIAD, Internet2 (successor of the Abilene Network), and the UK's national research and education network JANET. These in turn are built around smaller networks (see also the list of academic computer network organizations).

Many computer scientists describe the Internet as a "prime example of a large-scale, highly engineered, yet highly complex system". The Internet is extremely heterogeneous; for instance, data transfer rates and physical characteristics of connections vary widely. The Internet exhibits "emergent phenomena" that depend on its large-scale organization. For example, data transfer rates exhibit temporal self-similarity. The principles of the routing and addressing methods for traffic in the Internet reach back to their origins the 1960s when the eventual scale and popularity of the network could not be anticipated. Thus, the possibility of developing alternative structures is investigated.

governance

The Internet is a globally distributed network comprising many voluntarily interconnected autonomous networks. It operates without a central governing body. However, to maintain interoperability, all technical and policy aspects of the underlying core infrastructure and the principal name spaces are administered by the Internet Corporation for Assigned Names and Numbers (ICANN), headquartered in Marina del Rey, California. ICANN is the authority that coordinates the assignment of unique identifiers for use on the Internet, including domain names, Internet Protocol (IP) addresses, application port numbers in the transport protocols, and many other parameters. Globally unified name spaces, in which names and numbers are uniquely assigned, are essential for the global reach of the Internet. ICANN is governed by an international board of directors drawn from across the Internet technical, business, academic, and other non-commercial communities. The US government continues to have the primary role in approving changes to the DNS root zone that lies at the heart of the domain name system. ICANN's role in coordinating the assignment of unique identifiers distinguishes it as perhaps the only central coordinating body on the global Internet. On November 16, 2005, the World Summit on the Information Society, held in Tunis, established the Internet Governance Forum (IGF) to discuss Internet-related issues.

modern uses

The Internet is allowing greater flexibility in working hours and location, especially with the spread of unmetered high-speed connections and web applications.

The Internet can now be accessed almost anywhere by numerous means, especially through mobile Internet devices. Mobile phones, datacards, handheld game consoles and cellular routers allow users to connect to the Internet from anywhere there is a wireless network supporting that device's technology. Within the limitations imposed by small screens and other limited facilities of such pocket-sized devices, services of the Internet, including email and the web, may be available. Service providers may restrict the services offered and wireless data transmission charges may be significantly higher than other access methods.

The Internet has also become a large market for companies; some of the biggest companies today have grown by taking advantage of the efficient nature of low-cost advertising and commerce through the Internet, also known as e-commerce. It is the fastest way to spread information to a vast number of people simultaneously. The Internet has also subsequently revolutionized shopping—for example; a person can order a CD online and receive it in the mail within a couple of days, or download it directly in some cases. The Internet has also greatly facilitated personalized marketing which allows a company to market a product to a specific person or a specific group of people more so than any other advertising medium. Examples of personalized marketing include online communities such as MySpace, Friendster, Orkut, Facebook and others which thousands of Internet users join to advertise themselves and make friends online. Many of these users are young teens and adolescents ranging from 13 to 25 years old. In turn, when they advertise themselves they advertise interests and hobbies, which online marketing companies can use as information as to what those users will purchase online, and advertise their own companies' products to those users.

The low cost and nearly instantaneous sharing of ideas, knowledge, and skills has made collaborative work dramatically easier, with the help of collaborative software. Not only can a group cheaply communicate and share ideas, but the wide reach of the Internet allows such groups to easily form in the first place. An example of this is the free software movement, which has produced, among other programs, Linux, Mozilla Firefox, and OpenOffice.org. Internet "chat", whether in the form of IRC chat rooms or channels, or via instant messaging systems, allow colleagues to stay in touch in a very convenient way when working at their computers during the day. Messages can be exchanged even more quickly and conveniently than via e-mail. Extensions to these systems may allow files to be exchanged, "whiteboard" drawings to be shared or voice and video contact between team members.

Version control systems allow collaborating teams to work on shared sets of documents without either accidentally overwriting each other's work or having members wait until they get "sent" documents to be able to make their contributions. Business and project teams can share calendars as well as documents and other information. Such collaboration occurs in a wide variety of areas including scientific research, software development, conference planning, political activism and creative writing. Social and political collaboration is also becoming more widespread as both Internet access and computer literacy grow. From the flash mob 'events' of the early 2000s to the use of social networking in the 2009 Iranian election protests, the Internet allows people to work together more effectively and in many more ways than was possible without it.

The Internet allows computer users to remotely access other computers and information stores easily, wherever they may be across the world. They may do this with or without the use of security, authentication and encryption technologies, depending on the requirements. This is encouraging new ways of working from home, collaboration and information sharing in many industries. An accountant sitting at home can audit the books of a company based in another country, on a server situated in a third country that is remotely maintained by IT specialists in a fourth. These accounts could have been created by home-working bookkeepers, in other remote locations, based on information e-mailed to them from offices all over the world. Some of these things were possible before the widespread use of the Internet, but the cost of private leased lines would have made many of them infeasible in practice. An office worker away from their desk, perhaps on the other side of the world on a business trip or a holiday, can open a remote desktop session into his normal office PC using a secure Virtual Private Network (VPN) connection via the Internet. This gives the worker complete access to all of his or her normal files and data, including e-mail and other applications, while away from the office. This concept is also referred to by some network security people as the Virtual Private Nightmare, because it extends the secure perimeter of a corporate network into its employees' homes.

services

Information

Many people use the terms Internet and World Wide Web (or just the Web) interchangeably, but, as discussed earlier, the two terms are not synonymous. The World Wide Web is a global set of documents, images and other resources, referenced and interconnected by Uniform Resource Locators (URLs) and hyperlinks. These URLs allow users to address the web servers and other devices that store these resources and access them as required using the Hypertext Transfer Protocol (HTTP). HTTP is only one of the communication protocols used on the Internet. Web services may also use HTTP to allow software systems to communicate in order to share and exchange business logic and data.

Software products that can access the resources of the Web are often called user agents. In normal use, web browsers, such as Internet Explorer, Firefox, Opera, Apple Safari, and Google Chrome, let users navigate from one web page to another via hyperlinks. Documents on the web may contain any combination of computer data, including graphics, sounds, text, video, multimedia and interactive content including games, office applications and scientific demonstrations. Through keyword-driven Internet research using search engines like Yahoo! and Google, users worldwide have easy, instant access to a vast and diverse amount of online information. Compared to printed encyclopedias and traditional libraries, the World Wide Web has enabled a sudden and extreme decentralization of information and data.

Using the Web, it is also easier than ever before for individuals and organizations to publish ideas and information to a potentially large audience. Publishing a web page, a blog, or building a website involves little initial cost and many cost-free services are available. Publishing and maintaining large, professional web sites with attractive, diverse and up-to-date information is still a difficult and expensive proposition, however. Many individuals and some companies and groups use web logs or blogs, which are largely used as easily updatable online diaries. Some commercial organizations encourage staff to communicate advice in their areas of specialization in the hope that visitors will be impressed by the expert knowledge and free information, and be attracted to the corporation as a result. One example of this practice is Microsoft, whose product developers publish their personal blogs in order to pique the public's interest in their work. Collections of personal web pages published by large service providers remain popular, and have become increasingly sophisticated. Whereas operations such as Angelfire and GeoCities have existed since the early days of the Web, newer offerings from, for example, Facebook and MySpace currently have large followings. These operations often brand themselves as social network services rather than simply as web page hosts.

Advertising on popular web pages can be lucrative, and e-commerce or the sale of products and services directly via the Web continues to grow. In the early days, web pages were usually created as sets of complete and isolated HTML text files stored on a web server. More recently, websites are more often created using content management or wiki software with, initially, very little content. Contributors to these systems, who may be paid staff, members of a club or other organization or members of the public, fill underlying databases with content using editing pages designed for that purpose, while casual visitors view and read this content in its final HTML form. There may or may not be editorial, approval and security systems built into the process of taking newly entered content and making it available to the target visitors.

Communication

E-mail is an important communications service available on the Internet. The concept of sending electronic text messages between parties in a way analogous to mailing letters or memos predates the creation of the Internet. Today it can be important to distinguish between internet and internal e-mail systems. Internet e-mail may travel and be stored unencrypted on many other networks and machines out of both the sender's and the recipient's control. During this time it is quite possible for the content to be read and even tampered with by third parties, if anyone considers it important enough. Purely internal or intranet mail systems, where the information never leaves the corporate or organization's network, are much more secure, although in any organization there will be IT and other personnel whose job may involve monitoring, and occasionally accessing, the e-mail of other employees not addressed to them. Pictures, documents and other files can be sent as e-mail attachments. E-mails can be cc-ed to multiple e-mail addresses.

Internet telephony is another common communications service made possible by the creation of the Internet. VoIP stands for Voice-over-Internet Protocol, referring to the protocol that underlies all Internet communication. The idea began in the early 1990s with walkie-talkie-like voice applications for personal computers. In recent years many VoIP systems have become as easy to use and as convenient as a normal telephone. The benefit is that, as the Internet carries the voice traffic, VoIP can be free or cost much less than a traditional telephone call, especially over long distances and especially for those with always-on Internet connections such as cable or ADSL. VoIP is maturing into a competitive alternative to traditional telephone service. Interoperability between different providers has improved and the ability to call or receive a call from a traditional telephone is available. Simple, inexpensive VoIP network adapters are available that eliminate the need for a personal computer.

Voice quality can still vary from call to call but is often equal to and can even exceed that of traditional calls. Remaining problems for VoIP include emergency telephone number dialling and reliability. Currently, a few VoIP providers provide an emergency service, but it is not universally available. Traditional phones are line-powered and operate during a power failure; VoIP does not do so without a backup power source for the phone equipment and the Internet access devices. VoIP has also become increasingly popular for gaming applications, as a form of communication between players. Popular VoIP clients for gaming include Ventrilo and Teamspeak. Wii, PlayStation 3, and Xbox 360 also offer VoIP chat features.

Data transfer

File sharing is an example of transferring large amounts of data across the Internet. A computer file can be e-mailed to customers, colleagues and friends as an attachment. It can be uploaded to a website or FTP server for easy download by others. It can be put into a "shared location" or onto a file server for instant use by colleagues. The load of bulk downloads to many users can be eased by the use of "mirror" servers or peer-to-peer networks. In any of these cases, access to the file may be controlled by user authentication, the transit of the file over the Internet may be obscured by encryption, and money may change hands for access to the file. The price can be paid by the remote charging of funds from, for example, a credit card whose details are also passed—usually fully encrypted—across the Internet. The origin and authenticity of the file received may be checked by digital signatures or by MD5 or other message digests. These simple features of the Internet, over a worldwide basis, are changing the production, sale, and distribution of anything that can be reduced to a computer file for transmission. This includes all manner of print publications, software products, news, music, film, video, photography, graphics and the other arts. This in turn has caused seismic shifts in each of the existing industries that previously controlled the production and distribution of these products.

Streaming media refers to the act that many existing radio and television broadcasters promote Internet "feeds" of their live audio and video streams (for example, the BBC). They may also allow time-shift viewing or listening such as Preview, Classic Clips and Listen Again features. These providers have been joined by a range of pure Internet "broadcasters" who never had on-air licenses. This means that an Internet-connected device, such as a computer or something more specific, can be used to access on-line media in much the same way as was previously possible only with a television or radio receiver. The range of material is much wider, from pornography to highly specialized, technical webcasts. Podcasting is a variation on this theme, where—usually audio—material is downloaded and played back on a computer or shifted to a portable media player to be listened to on the move. These techniques using simple equipment allow anybody, with little censorship or licensing control, to broadcast audio-visual material worldwide.

Webcams can be seen as an even lower-budget extension of this phenomenon. While some webcams can give full-frame-rate video, the picture is usually either small or updates slowly. Internet users can watch animals around an African waterhole, ships in the Panama Canal, traffic at a local roundabout or monitor their own premises, live and in real time. Video chat rooms and video conferencing are also popular with many uses being found for personal webcams, with and without two-way sound. YouTube was founded on 15 February 2005 and is now the leading website for free streaming video with a vast number of users. It uses a flash-based web player to stream and show video files. Registered users may upload an unlimited amount of video and build their own personal profile. YouTube claims that its users watch hundreds of millions, and upload hundreds of thousands, of videos daily.

accessibility

The prevalent language for communication on the Internet is English. This may be a result of the origin of the Internet, as well as English's role as a lingua franca. It may also be related to the poor capability of early computers, largely originating in the United States, to handle characters other than those in the English variant of the Latin alphabet. After English (29% of Web visitors) the most requested languages on the World Wide Web are Chinese (22%), Spanish (8%), Japanese (6%), French (5%), Portuguese and German (4% each), Arabic (3%) and Russian and Korean (2% each). By region, 42% of the world's Internet users are based in Asia, 24% in Europe, 15% in North America, 11% in Latin America and the Caribbean taken together, 4% in Africa, 3% in the Middle East and 1% in Australia/Oceania. The Internet's technologies have developed enough in recent years, especially in the use of Unicode, that good facilities are available for development and communication in most widely used languages. However, some glitches such as mojibake (incorrect display of foreign language characters, also known as kryakozyabry) still remain.

Common methods of Internet access in homes include dial-up, landline broadband (over coaxial cable, fiber optic or copper wires), Wi-Fi, satellite and 3G technology cell phones. Public places to use the Internet include libraries and Internet cafes, where computers with Internet connections are available. There are also Internet access points in many public places such as airport halls and coffee shops, in some cases just for brief use while standing. Various terms are used, such as "public Internet kiosk", "public access terminal", and "Web payphone". Many hotels now also have public terminals, though these are usually fee-based. These terminals are widely accessed for various usage like ticket booking, bank deposit, online payment etc. Wi-Fi provides wireless access to computer networks, and therefore can do so to the Internet itself. Hotspots providing such access include Wi-Fi cafes, where would-be users need to bring their own wireless-enabled devices such as a laptop or PDA. These services may be free to all, free to customers only, or fee-based. A hotspot need not be limited to a confined location. A whole campus or park, or even an entire city can be enabled. Grassroots efforts have led to wireless community networks. Commercial Wi-Fi services covering large city areas are in place in London, Vienna, Toronto, San Francisco, Philadelphia, Chicago and Pittsburgh. The Internet can then be accessed from such places as a park bench. Apart from Wi-Fi, there have been experiments with proprietary mobile wireless networks like Ricochet, various high-speed data services over cellular phone networks, and fixed wireless services. High-end mobile phones such as smartphones generally come with Internet access through the phone network. Web browsers such as Opera are available on these advanced handsets, which can also run a wide variety of other Internet software. More mobile phones have Internet access than PCs, though this is not as widely used. An Internet access provider and protocol matrix differentiates the methods used to get online.

social impact

The Internet has made possible entirely new forms of social interaction, activities and organizing, thanks to its basic features such as widespread usability and access. Social networking websites such as Facebook and MySpace have created a new form of socialization and interaction. Users of these sites are able to add a wide variety of items to their personal pages, to indicate common interests, and to connect with others. It is also possible to find a large circle of existing acquaintances, especially if a site allows users to utilize their real names, and to allow communication among large existing groups of people. Sites like meetup.com exist to allow wider announcement of groups which may exist mainly for face-to-face meetings, but which may have a variety of minor interactions over their group's site at meetup.org, or other similar sites.

The first generation is now being raised with widespread availability of Internet connectivity, with consequences for privacy, identity, and copyright concerns. These "Digital natives" face a variety of concerns that were not present for prior generations.

In democratic societies, the Internet has achieved new relevance as a political tool, leading to Internet censorship by some states. The presidential campaign of Howard Dean in 2004 in the United States became famous for its ability to generate donations via the Internet. Many political groups use the Internet to achieve a whole new method of organizing, in order to carry out Internet activism. Some governments, such as those of Iran, North Korea, Myanmar, the People's Republic of China, and Saudi Arabia, restrict what people in their countries can access on the Internet, especially political and religious content. This is accomplished through software that filters domains and content so that they may not be easily accessed or obtained without elaborate circumvention.

In Norway, Denmark, Finland and Sweden, major Internet service providers have voluntarily (possibly to avoid such an arrangement being turned into law) agreed to restrict access to sites listed by police. While this list of forbidden URLs is only supposed to contain addresses of known child pornography sites, the content of the list is secret. Many countries, including the United States, have enacted laws making the possession or distribution of certain material, such as child pornography, illegal, but do not use filtering software. There are many free and commercially available software programs, called content-control software, with which a user can choose to block offensive websites on individual computers or networks, such as to limit a child's access to pornography or violence.

The Internet has been a major source of leisure since before the World Wide Web, with entertaining social experiments such as MUDs and MOOs being conducted on university servers, and humor-related Usenet groups receiving much of the main traffic. Today, many Internet forums have sections devoted to games and funny videos; short cartoons in the form of Flash movies are also popular. Over 6 million people use blogs or message boards as a means of communication and for the sharing of ideas. The pornography and gambling industries have both taken full advantage of the World Wide Web, and often provide a significant source of advertising revenue for other websites. Although many governments have attempted to put restrictions on both industries' use of the Internet, this has generally failed to stop their widespread popularity.

One main area of leisure on the Internet is multiplayer gaming. This form of leisure creates communities, bringing people of all ages and origins to enjoy the fast-paced world of multiplayer games. These range from MMORPG to first-person shooters, from role-playing games to online gambling. This has revolutionized the way many people interact and spend their free time on the Internet. While online gaming has been around since the 1970s, modern modes of online gaming began with services such as GameSpy and MPlayer, to which players of games would typically subscribe. Non-subscribers were limited to certain types of game play or certain games. Many use the Internet to access and download music, movies and other works for their enjoyment and relaxation. As discussed above, there are paid and unpaid sources for all of these, using centralized servers and distributed peer-to-peer technologies. Some of these sources take more care over the original artists' rights and over copyright laws than others.

Many use the World Wide Web to access news, weather and sports reports, to plan and book holidays and to find out more about their random ideas and casual interests. People use chat, messaging and e-mail to make and stay in touch with friends worldwide, sometimes in the same way as some previously had pen pals. Social networking websites like MySpace, Facebook and many others like them also put and keep people in contact for their enjoyment. The Internet has seen a growing number of Web desktops, where users can access their files, folders, and settings via the Internet. Cyberslacking can become a serious drain on corporate resources; the average UK employee spent 57 minutes a day surfing the Web while at work, according to a 2003 study by Peninsula Business Services.

ginseng

Ginseng is any one of eleven distinct species of slow-growing perennial plants with fleshy roots, in the Panax genus, in the family Araliaceae. It grows in the Northern Hemisphere in eastern Asia (mostly northern China, Korea, and eastern Siberia), typically in cooler climates; Panax vietnamensis, discovered in Vietnam, is the southernmost ginseng found. This article focuses on the Series Panax ginsengs, which are the adaptogenic herbs, principally Panax ginseng and P. quinquefolius. Ginseng is characterized by the presence of ginsenosides.

Siberian ginseng (Eleutherococcus senticosus) is not a true ginseng, but a different plant that was renamed as "Siberian ginseng" as a marketing ploy; instead of a fleshy root, it has a woody root; instead of ginsenosides, eleutherosides is the active compound. Eleutherosides are classified as another adaptogen.

etymology

The English word ginseng derives from the Chinese term rénshēn (simplified: 人参; traditional: 人蔘), literally "man root" (referring to the root's characteristic forked shape, resembling the legs of a man). The English pronunciation derives from a southern Chinese reading, similar to Cantonese jên shên (Jyutping: jan4sam1). It is closer to The Southern Min language, or Min Nan (Hokkien: Bân-lâm-gú), ("Southern Fujian" language) pronuntiation "jîn-sim"

The botanical/genus name Panax means "all-heal" in Greek, sharing the same origin as "panacea," and was applied to this genus because Linnaeus was aware of its wide use in Chinese medicine as a muscle relaxant.

traditional uses

Both American ginseng (Panax quinquefolius) and Asian ginseng (Panax ginseng) roots are taken orally as adaptogens, aphrodisiacs, nourishing stimulants, and in the treatment of type II diabetes, as well as sexual dysfunction in men. The root is most often available in dried form, either whole or sliced. Ginseng leaf, although not as highly prized, is sometimes also used; as with the root it is most often available in dried form.

This ingredient may also be found in some popular energy drinks: usually the "tea" varieties or functional foods. Usually ginseng is in subclinical doses and it does not have measurable medicinal effects. It can be found in cosmetic preparations as well, with similar lack of effect.

Ginseng root can be double steamed with chicken meat as a soup.

modern science and ginseng

It has been difficult to verify the medicinal benefits of ginseng using science, as there are contradictory results from different studies, possibly due to the wide variety and quality of ginseng used in studies. High-quality studies of the effects of ginseng are rare.

Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties, although animal experiments to determine whether longevity and health were increased in the presence of stress gave negative results.

A comparative, randomized and double-blind study at the National Autonomous University of Mexico indicates it may be "a promising dietary supplement" when assessed for an increase in quality of life.

A recent study at the University of Hong Kong has identified Ginseng to have anti-inflammatory effects. The study found that out of the nine ginsenosides they identified, seven could selectively inhibit expression of the inflammatory gene CXCL-10.

P. ginseng appear to inhibit some characteristics associated with cancer in animal models; nevertheless, this effect is unclear in humans. A randomized, double-blind pilot study noted ginseng appeared to reduce fatigue in cancer patients.

There are references in literature, including authoritative compendiums, that show interactions with ginseng. Herbalist Jonathan Treasure of the United States National Institute of Mental Health traces the growth of misinformation on an alleged adverse herb-drug interaction between the monoamine oxidase inhibitor phenelzine and Asian ginseng (P. ginseng C.A. Meyer). This originally was mentioned in a 1985 editorial by Shader and Greenblatt in the Journal of Clinical Psychopharmacology. Shader and Greenblatt devoted a couple of lines to the case of 64 year-old woman who took an undisclosed dose for an undisclosed time of a dietary supplement product called “Natrol High” while concurrently taking phenelzine 60 mg qd. She experienced symptoms of “insomnia, headache, and tremulousness”. Treasure contacted Natrol by email and discovered within ten minutes that there was no P. ginseng in the formula, but instead Eleutherococcus senticosus which was then called by the popular name "Siberian ginseng" and it was given in a subclinical dosage mixed with a variety of other herbs. The purported interaction effects are well-known side effects of phenelzine alone, which had been given in a high dosage and are not at all suggestive of Eleutherococcus. However this misinformed article with a misidentified herb has been picked up in literature searches, megastudies and is now documented by conventional medical authorities such as Stockley’s, and is repeated in several botanical monographs e.g. World Health Organization (WHO 1999).

ginseng and reproductive activity

A 2002 study by the Southern Illinois University School of Medicine (published in the annals of the New York Academy of Sciences) found that in laboratory animals, both Asian and American forms of ginseng enhance libido and copulatory performance. These effects of ginseng may not be due to changes in hormone secretion, but to direct effects of ginseng, or its ginsenoside components, on the central nervous system and gonadal tissues. In males, ginsenosides can facilitate penile erection. This is consistent with traditional Chinese medicine and Native American medicinal uses of ginseng.

Ginseng is known to contain phytoestrogens.

side effects

According to a Sports Nutrition FAQ published by UMass Amherst, one of P. ginseng's most common side-effects is the inability to sleep. However, other sources state that ginseng causes no sleep difficulties. Other side-effects can include nausea, diarrhea, euphoria, headaches, epistaxis, high blood pressure, low blood pressure, and mastalgia.

Overdose

The common adaptogen ginsengs (P. ginseng and P. quinquefolia) are generally considered to be relatively safe even in large amounts. P. ginseng is not recommended within Chinese Medicine to be administered along with anti-infective herbs unless a person is quite debilitated, because of the fear that the pathogen will be tonified. Herbalists in China believed this and according to Xu Dachun in his brief essay on ginseng (1757 A.D., during the Qing Dynasty): "if one administers Ginseng of a purely supplementing nature, then one will merely supplement the evil influences and help them settle down. In minor cases, the evil influences will, as a result of such mistaken therapy, never leave the body again. In serious cases, death is inevitable."

common classification

P. quinquefolius American ginseng (root)

According to Traditional Chinese Medicine, American Ginseng promotes Yin energy, cleans excess Yang in the body, and calms the body. The reason it has been claimed that American ginseng promotes Yin (shadow, cold, negative, female) while East Asian ginseng promotes Yang (sunshine, hot, positive, male) is because, according to traditional Chinese medicine, things living in cold places or northern side of mountains or southern side of rivers are strong in Yang and vice versa, so that the two are balanced. Chinese/Korean ginseng grows in northeast China and Korea, the coldest area known to many Koreans in traditional times. Thus, ginseng from there is supposed to be very Yang. Originally, American ginseng was imported into China via subtropical Guangzhou, the seaport next to Hong Kong, so Chinese doctors believed that American ginseng must be good for Yin, because it came from a hot area. However they did not know that American ginseng can only grow in temperate regions. Nonetheless the root is legitimately classified as more Yin because it generates fluids.

The two main components of ginseng are in different proportions in the Asian and American varieties, and may well be the cause of the excitatory versus tonic natures.

The ginseng is sliced and a few slices are simmered in hot water to make a decoction.
Most North American ginseng is produced in the Canadian provinces of Ontario and British Columbia and the American state of Wisconsin, according to Agri-food Canada. P. quinquefolius is now also grown in northern China.
A randomized, double-blind study shows that an extract of American ginseng reduces influenza cases in the elderly when compared to placebo.

The treasured aromatic root resembles a small parsnip that forks as it matures. The plant grows 6 to 18 inches tall, usually bearing three leaves, each with three to five leaflets 2 to 5 inches long.

panax ginseng asian ginseng (root)

According to Traditional Chinese Medicine Panax Ginseng promotes Yang energy, improves circulation, increases blood supply, revitalizes and aids recovery from weakness after illness, and stimulates the body. Panax Ginseng is available in two forms:

The form called white ginseng is grown for four to six years, and then peeled and dried to reduce the water content to 12% or less. White Ginseng is air dried in the sun and may contain less of the therapeutic constituents. It is thought by some that enzymes contained in the root break down these constituents in the process of drying. Drying in the sun bleaches the root to a yellowish-white color.

The form called red ginseng is harvested after six years, is not peeled and is steam-cured, thereby giving them a glossy reddish-brown coloring. Steaming the root is thought to change its biochemical composition and also to prevent the breakdown of the active ingredients. The roots are then dried.

red ginseng

Red ginseng (Korean=홍삼(hong-sam), simplified Chinese: 红蔘; traditional Chinese: 紅蔘), is Panax ginseng that has been heated, either through steaming or sun-drying. It is frequently marinated in an herbal brew which results in the root becoming extremely brittle. This version of ginseng is traditionally associated with stimulating sexual function and increasing energy. Red ginseng is always produced from cultivated roots, usually from either China or South Korea.

In 2002, a preliminary double-blind, crossover study of Korean red ginseng's effects on impotence reported that it can be an effective alternative for treating male erectile dysfunction.

A study shows that Red ginseng reduces the relapse of gastric cancer versus control.

A study of ginseng's effects on rats shows that while both white ginseng and red ginseng reduce the incidence of cancer, the effects appear to be greater with red ginseng.

A study by Sung H, Jung YS, Cho YK. shows potentially beneficial effects of a combination of Korean Red Ginseng and highly active antiretroviral therapy in HIV-1-Infected patients.


Falcarinol, a seventeen-carbon diyne fatty alcohol was isolated from carrot and red ginseng, shown to have potent anticancer properties on primary mammary epithelial (breast cancer) cells. Other acetylenic fatty alcohols in ginseng (panaxacol, panaxydol, panaxytriol) have antibiotic properties.

wild ginseng

Wild ginseng is ginseng that has not been planted and cultivated domestically, rather it is that which grows naturally and is harvested from wherever it is found to be growing. Wild ginseng is relatively rare and even increasingly endangered, due in large part to high demand for the product in recent years, which has led to the wild plants being sought out and harvested faster than new ones can grow (it requires years for a ginseng root to reach maturity). Wild ginseng can be either Asian or American and can be processed to be red ginseng.

There are woods grown American ginseng programs in Maine, Tennessee, Virginia, North Carolina and West Virginia. and United Plant Savers has been encouraging the woods planting of ginseng both to restore natural habitats and to remove pressure from any remaining wild ginseng, and they offer both advice and sources of rootlets. Woods grown plants have comparable value to wild grown ginseng of similar age.

ginseng alternatives

These mostly adaptogenic plants are sometimes referred to as ginsengs, but they are either from a different family or genus. Only Jiaogulan actually contains compounds closely related to ginsenosides, although ginsenosides alone do not determine the effectiveness of ginseng. Since each of these plants have different uses, one should research their properties before using.

* Gynostemma pentaphyllum (Southern ginseng, aka Jiaogulan)
* Eleutherococcus senticosus (Siberian ginseng)
* Pseudostellaria heterophylla (Prince ginseng)
* Withania somnifera (Indian ginseng, aka Ashwagandha)
* Pfaffia paniculata (Brazilian ginseng, aka Suma)
* Lepidium meyenii (Peruvian ginseng, aka Maca)
* Oplopanax horridus (Alaskan ginseng)

Other plants which are referred to as ginsengs may not be adaptogens (although notoginseng is in the genus Panax):

* Angelica sinensis (Female ginseng, aka Dong Quai)
* Panax notoginseng (Known as san qi, tian qi or tien chi, hemostatic ingredient in Yunnan Bai Yao)

swine influenza

Swine influenza (also called swine flu, hog flu, pig flu and sometimes, the swine) is an infection by any one of several types of swine influenza virus. Swine influenza virus (SIV) is any strain of the influenza family of viruses that is endemic in pigs. As of 2009, the known SIV strains include influenza C and the subtypes of influenza A known as H1N1, H1N2, H3N1, H3N2, and H2N3.

Swine influenza virus is common throughout pig populations worldwide. Transmission of the virus from pigs to humans is not common and does not always lead to human influenza, often resulting only in the production of antibodies in the blood. If transmission does cause human influenza, it is called zoonotic swine flu. People with regular exposure to pigs are at increased risk of swine flu infection. The meat of an infected animal poses no risk of infection when properly cooked.

During the mid-20th century, identification of influenza subtypes became possible, allowing accurate diagnosis of transmission to humans. Since then, only 50 such transmissions have been confirmed. These strains of swine flu rarely pass from human to human. Symptoms of zoonotic swine flu in humans are similar to those of influenza and of influenza-like illness in general, namely chills, fever, sore throat, muscle pains, severe headache, coughing, weakness and general discomfort.

classification

Of the three genera of influenza viruses that cause human flu, two also cause influenza in pigs, with influenza A being common in pigs and influenza C being rare. Influenza B has not been reported in pigs. Within influenza A and influenza C, the strains found in pigs and humans are largely distinct, although due to reassortment there have been transfers of genes among strains crossing swine, avian, and human species boundaries.

influenza c

Influenza C viruses infect both humans and pigs, but do not infect birds. Transmission between pigs and humans have occurred in the past. For example, influenza C caused small outbreaks of a mild form of influenza amongst children in Japan and California. Due to its limited host range and the lack of genetic diversity in influenza C, this form of influenza does not cause pandemics in humans.

influenza a

Swine influenza is known to be caused by influenza A subtypes H1N1, H1N2, H2N3, H3N1, and H3N2. In pigs, three influenza A virus subtypes (H1N1, H1N2, and H3N2) are the most common strains worldwide. In the United States, the H1N1 subtype was exclusively prevalent among swine populations before 1998; however, since late August 1998, H3N2 subtypes have been isolated from pigs. As of 2004, H3N2 virus isolates in US swine and turkey stocks were triple reassortants, containing genes from human (HA, NA, and PB1), swine (NS, NP, and M), and avian (PB2 and PA) lineages.

surveillance

Although there is no formal national surveillance system in the United States to determine what viruses are circulating in pigs, there is an informal surveillance network in the United States that is part of a world surveillance network.

Veterinary medical pathologist, Tracey McNamara, set up a national disease surveillance system in zoos because the zoos do active disease surveillance and many of the exotic animals housed there have broad susceptibilities. Many species fall below the radar of any federal agencies (including dogs, cats, pet prairie dogs, zoo animals, and urban wildlife), even though they may be important in the early detection of human disease outbreaks.

history

Swine influenza was first proposed to be a disease related to human influenza during the 1918 flu pandemic, when pigs became sick at the same time as humans. The first identification of an influenza virus as a cause of disease in pigs occurred about ten years later, in 1930. For the following 60 years, swine influenza strains were almost exclusively H1N1. Then, between 1997 and 2002, new strains of three different subtypes and five different genotypes emerged as causes of influenza among pigs in North America. In 1997–1998, H3N2 strains emerged. These strains, which include genes derived by reassortment from human, swine and avian viruses, have become a major cause of swine influenza in North America. Reassortment between H1N1 and H3N2 produced H1N2. In 1999 in Canada, a strain of H4N6 crossed the species barrier from birds to pigs, but was contained on a single farm.

The H1N1 form of swine flu is one of the descendants of the strain that caused the 1918 flu pandemic. As well as persisting in pigs, the descendants of the 1918 virus have also circulated in humans through the 20th century, contributing to the normal seasonal epidemics of influenza. However, direct transmission from pigs to humans is rare, with only 12 cases in the U.S. since 2005. Nevertheless, the retention of influenza strains in pigs after these strains have disappeared from the human population might make pigs a reservoir where influenza viruses could persist, later emerging to reinfect humans once human immunity to these strains has waned.

Swine flu has been reported numerous times as a zoonosis in humans, usually with limited distribution, rarely with a widespread distribution. Outbreaks in swine are common and cause significant economic losses in industry, primarily by causing stunting and extended time to market. For example, this disease costs the British meat industry about £65 million every year.

1918 pandemic in humans

The 1918 flu pandemic in humans was associated with H1N1 and influenza appearing in pigs; this may reflect a zoonosis either from swine to humans, or from humans to swine. Although it is not certain in which direction the virus was transferred, some evidence suggests that, in this case, pigs caught the disease from humans. For instance, swine influenza was only noted as a new disease of pigs in 1918, after the first large outbreaks of influenza amongst people. Although a recent phylogenetic analysis of more recent strains of influenza in humans, birds, and swine suggests that the 1918 outbreak in humans followed a reassortment event within a mammal, the exact origin of the 1918 strain remains elusive. It is estimated that anywhere from 50 to 100 million people were killed worldwide.

1976 U.S. outbreak

On February 5, 1976, in the United States an army recruit at Fort Dix said he felt tired and weak. He died the next day and four of his fellow soldiers were later hospitalized. Two weeks after his death, health officials announced that the cause of death was a new strain of swine flu. The strain, a variant of H1N1, is known as A/New Jersey/1976 (H1N1). It was detected only from January 19 to February 9 and did not spread beyond Fort Dix.

This new strain appeared to be closely related to the strain involved in the 1918 flu pandemic. Moreover, the ensuing increased surveillance uncovered another strain in circulation in the U.S.: A/Victoria/75 (H3N2) spread simultaneously, also caused illness, and persisted until March. Alarmed public-health officials decided action must be taken to head off another major pandemic, and urged President Gerald Ford that every person in the U.S. be vaccinated for the disease.

The vaccination program was plagued by delays and public relations problems. On October 1, 1976, immunizations began and three senior citizens died soon after receiving their injections. This resulted in a media outcry that linked these deaths to the immunizations, despite the lack of any proof that the vaccine was the cause. According to science writer Patrick Di Justo, however, by the time the truth was known—that the deaths were not proven to be related to the vaccine—it was too late. "The government had long feared mass panic about swine flu—now they feared mass panic about the swine flu vaccinations." This became a strong setback to the program.

There were reports of Guillain-Barré syndrome, a paralyzing neuromuscular disorder, affecting some people who had received swine flu immunizations. This syndrome is a rare side-effect of modern influenza vaccines, with an incidence of about one case per million vaccinations. As a result, Di Justo writes that "the public refused to trust a government-operated health program that killed old people and crippled young people." In total, 48,161,019 Americans, or just over 22% of the population, had been immunized by the time the National Influenza Immunization Program (NIIP) was effectively halted on December 16, 1976.

Overall, there were 1098 cases of Guillain-Barré Syndrome (GBS) recorded nationwide by CDC surveillance, 532 of which were linked to the NIIP vaccination, resulting in death from severe pulmonary complications for 25 people, which, according to Dr. P. Haber, were probably caused by an immunopathological reaction to the 1976 vaccine. Other influenza vaccines have not been linked to GBS, though caution is advised for certain individuals, particularly those with a history of GBS. Still, as observed by a participant in the immunization program, the vaccine killed more Americans than the disease did.

1988 zoonosis

In September 1988, a swine flu virus killed one woman and infected others. 32-year old Barbara Ann Wieners was eight months pregnant when she and her husband, Ed, became ill after visiting the hog barn at a county fair in Walworth County, Wisconsin. Barbara died eight days later, after developing pneumonia. The only pathogen identified was an H1N1 strain of swine influenza virus. Doctors were able to induce labor and deliver a healthy daughter before she died. Her husband recovered from his symptoms.

Influenza-like illness (ILI) was reportedly widespread among the pigs exhibited at the fair. 76% of 25 swine exhibitors aged 9 to 19 tested positive for antibody to SIV, but no serious illnesses were detected among this group. Additional studies suggested between one and three health care personnel who had contact with the patient developed mild influenza-like illnesses with antibody evidence of swine flu infection. However, there was no community outbreak.

1998 U.S. outbreak in swine

In 1998, swine flu was found in pigs in four U.S. states. Within a year, it had spread through pig populations across the United States. Scientists found that this virus had originated in pigs as a recombinant form of flu strains from birds and humans. This outbreak confirmed that pigs can serve as a crucible where novel influenza viruses emerge as a result of the reassortment of genes from different strains. Genetic components of these 1998 triple-hybrid stains would later form six out of the eight viral gene segments in the 2009 flu outbreak.

2007 Phillippine outbreak in swine

On August 20, 2007 Department of Agriculture officers investigated the outbreak (epizootic) of swine flu in Nueva Ecija and Central Luzon, Philippines. The mortality rate is less than 10% for swine flu, unless there are complications like hog cholera. On July 27, 2007, the Philippine National Meat Inspection Service (NMIS) raised a hog cholera "red alert" warning over Metro Manila and 5 regions of Luzon after the disease spread to backyard pig farms in Bulacan and Pampanga, even if these tested negative for the swine flu virus.

2009 outbreak in humans

The H1N1 viral strain implicated in the 2009 flu pandemic among humans often is called "swine flu" because initial testing showed many of the genes in the virus were similar to influenza viruses normally occurring in North American swine. Further research has shown that three-quarters or six out of the eight gene segments of the 2009 virus arose from the 1998 North American swine flu strains which emerged from the first-ever reported triple-hybrid virus of 1998.

In late April, Margaret Chan, the World Health Organization's director-general, declared a "public health emergency of international concern" under the rules of the WHO's new International Health Regulations when the first cases of the H1N1 virus were reported in the United States. Following the outbreak, on May 2, 2009, it was reported in pigs at a farm in Alberta, Canada, with a link to the outbreak in Mexico. The pigs are suspected to have caught this new strain of virus from a farm worker who recently returned from Mexico, then showed symptoms of an influenza-like illness. These are probable cases, pending confirmation by laboratory testing.

The new strain was initially described as an apparent reassortment of at least four strains of influenza A virus subtype H1N1, including one strain endemic in humans, one endemic in birds, and two endemic in swine. Subsequent analysis suggested it was a reassortment of just two strains, both found in swine. Although initial reports identified the new strain as swine influenza (i.e., a zoonosis originating in swine), its genetic origin was only later revealed to have been mostly a descendant of the triple-reassortment virus which emerged in factory farms in the United States in 1998. Several countries took precautionary measures to reduce the chances for a global pandemic of the disease. The 2009 swine flu has been compared to other similar types of influenza virus in terms of mortality: "in the US it appears that for every 1000 people who get infected, about 40 people need admission to hospital and about one person dies." There are fears that swine flu will become a major global pandemic at the end of the year (coinciding with the Northern Hemisphere winter months), with many countries planning major vaccination campaigns.

transmission between pigs

Influenza is quite common in pigs, with about half of breeding pigs having been exposed to the virus in the US. Antibodies to the virus are also common in pigs in other countries.

The main route of transmission is through direct contact between infected and uninfected animals. These close contacts are particularly common during animal transport. Intensive farming may also increase the risk of transmission, as the pigs are raised in very close proximity to each other. The direct transfer of the virus probably occurs either by pigs touching noses, or through dried mucus. Airborne transmission through the aerosols produced by pigs coughing or sneezing are also an important means of infection. The virus usually spreads quickly through a herd, infecting all the pigs within just a few days. Transmission may also occur through wild animals, such as wild boar, which can spread the disease between farms.

transmission to humans

People who work with poultry and swine, especially people with intense exposures, are at increased risk of zoonotic infection with influenza virus endemic in these animals, and constitute a population of human hosts in which zoonosis and reassortment can co-occur. Vaccination of these workers against influenza and surveillance for new influenza strains among this population may therefore be an important public health measure. Transmission of influenza from swine to humans who work with swine was documented in a small surveillance study performed in 2004 at the University of Iowa. This study among others forms the basis of a recommendation that people whose jobs involve handling poultry and swine be the focus of increased public health surveillance. Other professions at particular risk of infection are veterinarians and meat processing workers, although the risk of infection for both of these groups is lower than that of farm workers.

interaction with avian H5N1 in pigs

Pigs are unusual as they can be infected with influenza strains that usually infect three different species: pigs, birds and humans. This makes pigs a host where influenza viruses might exchange genes, producing new and dangerous strains. Avian influenza virus H3N2 is endemic in pigs in China and has been detected in pigs in Vietnam, increasing fears of the emergence of new variant strains. H3N2 evolved from H2N2 by antigenic shift. In August 2004, researchers in China found H5N1 in pigs.

These H5N1 infections may be quite common: in a survey of 10 apparently healthy pigs housed near poultry farms in West Java, where avian flu had broken out, five of the pig samples contained the H5N1 virus. The Indonesian government has since found similar results in the same region. Additional tests of 150 pigs outside the area were negative.

signs and symptoms

in swine

In pigs influenza infection produces fever, lethargy, sneezing, coughing, difficulty breathing and decreased appetite. In some cases the infection can cause abortion. Although mortality is usually low (around 1–4%), the virus can produce weight loss and poor growth, causing economic loss to farmers. Infected pigs can lose up to 12 pounds of body weight over a 3 to 4 week period.

in humans

Direct transmission of a swine flu virus from pigs to humans is occasionally possible (called zoonotic swine flu). In all, 50 cases are known to have occurred since the first report in medical literature in 1958, which have resulted in a total of six deaths. Of these six people, one was pregnant, one had leukemia, one had Hodgkin disease and two were known to be previously healthy. Despite these apparently low numbers of infections, the true rate of infection may be higher, since most cases only cause a very mild disease, and will probably never be reported or diagnosed.

According to the Centers for Disease Control and Prevention (CDC), in humans the symptoms of the 2009 "swine flu" H1N1 virus are similar to those of influenza and of influenza-like illness in general. Symptoms include fever, cough, sore throat, body aches, headache, chills and fatigue. The 2009 outbreak has shown an increased percentage of patients reporting diarrhea and vomiting. The 2009 H1N1 virus is not zoonotic swine flu, as it is not transmitted from pigs to humans, but from person to person.

Because these symptoms are not specific to swine flu, a differential diagnosis of probable swine flu requires not only symptoms but also a high likelihood of swine flu due to the person's recent history. For example, during the 2009 swine flu outbreak in the United States, CDC advised physicians to "consider swine influenza infection in the differential diagnosis of patients with acute febrile respiratory illness who have either been in contact with persons with confirmed swine flu, or who were in one of the five U.S. states that have reported swine flu cases or in Mexico during the 7 days preceding their illness onset." A diagnosis of confirmed swine flu requires laboratory testing of a respiratory sample (a simple nose and throat swab).

The most common cause of death is respiratory failure. Other causes of death are pneumonia (leading to sepsis), high fever (leading to neurological problems), dehydration (from excessive vomiting and diarrhea) and electrolyte imbalance. Fatalities are more likely in young children and the elderly.

diagnosis

Different medical kits are available for diagnosis of swine flu.

The two major tests that are being used are the nasopharyngeal (or back of the throat) swab for viral culture, the gold standard, and the indirect evidence test by detection of antibodies to novel H1N1 with PCR studies.

prevention

in swine

Methods of preventing the spread of influenza among swine include facility management, herd management, and vaccination (ATCvet code: QI09AA03). Because much of the illness and death associated with swine flu involves secondary infection by other pathogens, control strategies that rely on vaccination may be insufficient.

Control of swine influenza by vaccination has become more difficult in recent decades, as the evolution of the virus has resulted in inconsistent responses to traditional vaccines. Standard commercial swine flu vaccines are effective in controlling the infection when the virus strains match enough to have significant cross-protection, and custom (autogenous) vaccines made from the specific viruses isolated are created and used in the more difficult cases. Present vaccination strategies for SIV control and prevention in swine farms typically include the use of one of several bivalent SIV vaccines commercially available in the United States. Of the 97 recent H3N2 isolates examined, only 41 isolates had strong serologic cross-reactions with antiserum to three commercial SIV vaccines. Since the protective ability of influenza vaccines depends primarily on the closeness of the match between the vaccine virus and the epidemic virus, the presence of nonreactive H3N2 SIV variants suggests that current commercial vaccines might not effectively protect pigs from infection with a majority of H3N2 viruses. The United States Department of Agriculture researchers say that while pig vaccination keeps pigs from getting sick, it does not block infection or shedding of the virus.

Facility management includes using disinfectants and ambient temperature to control virus in the environment. The virus is unlikely to survive outside living cells for more than two weeks, except in cold (but above freezing) conditions, and it is readily inactivated by disinfectants. Herd management includes not adding pigs carrying influenza to herds that have not been exposed to the virus. The virus survives in healthy carrier pigs for up to 3 months and can be recovered from them between outbreaks. Carrier pigs are usually responsible for the introduction of SIV into previously uninfected herds and countries, so new animals should be quarantined. After an outbreak, as immunity in exposed pigs wanes, new outbreaks of the same strain can occur.

in humans

Prevention of pig to human transmission

Swine can be infected by both avian and human influenza strains of influenza, and therefore are hosts where the antigenic shifts can occur that create new influenza strains.

The transmission from swine to human is believed to occur mainly in swine farms where farmers are in close contact with live pigs. Although strains of swine influenza are usually not able to infect humans this may occasionally happen, so farmers and veterinarians are encouraged to use a face mask when dealing with infected animals. The use of vaccines on swine to prevent their infection is a major method of limiting swine to human transmission. Risk factors that may contribute to swine-to-human transmission include smoking and not wearing gloves when working with sick animals.

Prevention of human to human transmission

Influenza spreads between humans through coughing or sneezing and people touching something with the virus on it and then touching their own nose or mouth. Swine flu cannot be spread by pork products, since the virus is not transmitted through food. The swine flu in humans is most contagious during the first five days of the illness although some people, most commonly children, can remain contagious for up to ten days. Diagnosis can be made by sending a specimen, collected during the first five days for analysis.

Recommendations to prevent spread of the virus among humans include using standard infection control against influenza. This includes frequent washing of hands with soap and water or with alcohol-based hand sanitizers, especially after being out in public. Chance of transmission is also reduced by disinfecting household surfaces, which can be done effectively with a diluted chlorine bleach solution.

Experts agree that hand-washing can help prevent viral infections, including ordinary influenza and the swine flu virus. Also avoiding touching eyes, nose and mouth with hands prevents flu. Influenza can spread in coughs or sneezes, but an increasing body of evidence shows small droplets containing the virus can linger on tabletops, telephones and other surfaces and be transferred via the fingers to the mouth, nose or eyes. Alcohol-based gel or foam hand sanitizers work well to destroy viruses and bacteria. Anyone with flu-like symptoms such as a sudden fever, cough or muscle aches should stay away from work or public transportation and should contact a doctor for advice.

Social distancing is another tactic. It means staying away from other people who might be infected and can include avoiding large gatherings, spreading out a little at work, or perhaps staying home and lying low if an infection is spreading in a community. Public health and other responsible authorities have action plans which may request or require social distancing actions depending on the severity of the outbreak.

Vaccination

Vaccines are available for different kinds of swine flu. The Food and Drug Administration (FDA) approved the new swine flu vaccine on September 15, 2009. Studies by the National Institutes of Health (NIH), show that a single dose creates enough antibodies to protect against the virus within about 10 days.

treatment

In swine

As swine influenza is rarely fatal to pigs, little treatment beyond rest and supportive care is required. Instead veterinary efforts are focused on preventing the spread of the virus throughout the farm, or to other farms. Vaccination and animal management techniques are most important in these efforts. Antibiotics are also used to treat this disease, which although they have no effect against the influenza virus, do help prevent bacterial pneumonia and other secondary infections in influenza-weakened herds.

In humans

If a person becomes sick with swine flu, antiviral drugs can make the illness milder and make the patient feel better faster. They may also prevent serious flu complications. For treatment, antiviral drugs work best if started soon after getting sick (within 2 days of symptoms). Beside antivirals, supportive care at home or in hospital, focuses on controlling fevers, relieving pain and maintaining fluid balance, as well as identifying and treating any secondary infections or other medical problems. The U.S. Centers for Disease Control and Prevention recommends the use of Tamiflu (oseltamivir) or Relenza (zanamivir) for the treatment and/or prevention of infection with swine influenza viruses; however, the majority of people infected with the virus make a full recovery without requiring medical attention or antiviral drugs. The virus isolates in the 2009 outbreak have been found resistant to amantadine and rimantadine.

In the U.S., on April 27, 2009, the Food and Drug Administration (FDA) issued Emergency Use Authorizations to make available Relenza and Tamiflu antiviral drugs to treat the swine influenza virus in cases for which they are currently unapproved. The agency issued these EUAs to allow treatment of patients younger than the current approval allows and to allow the widespread distribution of the drugs, including by non-licensed volunteers.

unidentified flying object

This article is semi-protected.

Unidentified flying object (commonly abbreviated as UFO or U.F.O.) is the popular term for any aerial phenomenon whose cause cannot be easily or immediately identified by the observer. The United States Air Force, which coined the term in 1952, initially defined UFOs as those objects that remain unidentified after scrutiny by expert investigators, though the term UFO is often used more generally to describe any sighting unidentifiable to the reporting observer(s). Popular culture frequently takes the term UFO as a synonym for alien spacecraft. Cults have become associated with UFOs, and mythology and folklore have evolved around the phenomenon. Some investigators now prefer to use the broader term unidentified aerial phenomenon (or UAP), to avoid the confusion and speculative associations that have become attached to UFO. Another widely known acronym for UFO in Spanish, French, Portuguese and Italian is OVNI.

Studies have established that the majority of UFOs are observations of some real but conventional object—most commonly aircraft, balloons, or astronomical objects such as meteors or bright planets—that have been misidentified by the observer as anomalies while a small percentage of reported UFOs are hoaxes. Only a small percentage of reported sightings (usually 5 to 20%) can be classified as unidentified flying objects in the strictest sense (see below for some studies).

Some scientists have argued that all UFO sightings are misidentifications of natural phenomena and historically, there was debate among some scientists about whether scientific investigation was warranted given available empirical data. Very little peer-reviewed literature has been published in which scientists have proposed, studied or supported non-prosaic explanations for UFOs. Allen Hynek was a trained astronomer who participated in Project Bluebook after doing research as a federal government employee. He formed the opinion that some UFO reports could not be scientifically explained. Through his founding of the Center for UFO Studies and participation at CUFOs he spent the rest of his life researching and documenting UFOs. The movie Close Encounters of the Third Kind had a character loosely based on Hynek. Another group studying UFOs is Mutual UFO Network. MUFON is a grass roots based organization known for publishing one of the first UFO investigators handbooks. This handbook went into great detail on how to document alleged UFO sightings.

UFO reports became frequent after the first widely publicized U.S. sighting, reported by private pilot Kenneth Arnold in 1947, that gave rise to the popular terms "flying saucer" and "flying disc." Since then, millions of people have reported that they have seen UFOs.

history

Unexplained aerial observations have been reported throughout history. Some were undoubtedly astronomical in nature: comets, bright meteors, one or more of the five planets that can be seen with the naked eye, planetary conjunctions, or atmospheric optical phenomena such as parhelia and lenticular clouds. An example is Halley's Comet, which was recorded first by Chinese astronomers in 240 B.C. and possibly as early as 467 B.C.

Other historical reports seem to defy prosaic explanation, but assessing such accounts is difficult. Whatever their actual cause, such sightings throughout history were often treated as supernatural portents, angels, or other religious omens. Some objects in medieval paintings can seem strikingly similar to UFO reports. Art historians explain those objects as religious symbols, often represented in many other paintings of Middle-Age and Renaissance.

Shen Kuo (1031–1095), a Song Chinese government scholar-official and prolific polymath inventor and scholar, wrote a vivid passage in his Dream Pool Essays (1088) about an unidentified flying object. He recorded the testimony of eyewitnesses in 11th-century Anhui and Jiangsu (especially in the city of Yangzhou), who stated that a flying object with opening doors would shine a blinding light from its interior (from an object shaped like a pearl) that would cast shadows from trees for ten miles in radius, and was able to take off at tremendous speeds.

* On January 25, 1878, The Denison Daily News wrote that local farmer John Martin had reported seeing a large, dark, circular flying object resembling a balloon flying "at wonderful speed." Martin also said it appeared to be about the size of a saucer, the first known use of the word "saucer" in association with a UFO.
* On February 28, 1904, there was a sighting by three crew members on the USS Supply 300 miles west of San Francisco, reported by Lt. Frank Schofield, later to become Commander-in-Chief of the Pacific Battle Fleet. Schofield wrote of three bright red egg-shaped and circular objects flying in echelon formation that approached beneath the cloud layer, then changed course and "soared" above the clouds, departing directly away from the earth after two to three minutes. The largest had an apparent size of about six suns.
* 1916 and 1926: The three oldest known pilot UFO sightings, of 1305 cataloged by NARCAP. On January 31, 1916, a UK pilot near Rochford reported a row of lights, like lighted windows on a railway carriage, that rose and disappeared. In January 1926, a pilot reported six "flying manhole covers" between Wichita, Kansas and Colorado Springs, Colorado. In late September 1926, an airmail pilot over Nevada was forced to land by a huge, wingless cylindrical object.
* On August 5, 1926, while traveling in the Humboldt Mountains of Tibet's Kokonor region, Nicholas Roerich reported that members of his expedition saw "something big and shiny reflecting the sun, like a huge oval moving at great speed. Crossing our camp the thing changed in its direction from south to southwest. And we saw how it disappeared in the intense blue sky. We even had time to take our field glasses and saw quite distinctly an oval form with shiny surface, one side of which was brilliant from the sun.” Another description by Roerich was, "...A shiny body flying from north to south. Field glasses are at hand. It is a huge body. One side glows in the sun. It is oval in shape. Then it somehow turns in another direction and disappears in the southwest."
* In the Pacific and European theatres during World War II, "Foo-fighters" (metallic spheres, balls of light and other shapes that followed aircraft) were reported and on occasion photographed by Allied and Axis pilots. Some proposed Allied explanations at the time included St. Elmo's Fire, the planet Venus, hallucinations from oxygen deprivation, or German secret weapon.
* On February 25, 1942, U.S. Army observers reported unidentified aircraft both visually and on radar over the Los Angeles, California region. Antiaircraft artillery was fired at what was presumed to be Japanese planes. No readily apparent explanation was offered, though some officials dismissed the reports of aircraft as being triggered by anxieties over expected Japanese air attacks on California. However, Army Chief of Staff Gen. George C. Marshall and Secretary of War Henry Stimson insisted real aircraft were involved. The incident later became known as the Battle of Los Angeles, or the West coast air raid.
* In 1946, there were over 2000 reports, collected primarily by the Swedish military, of unidentified aerial objects in the Scandinavian nations, along with isolated reports from France, Portugal, Italy and Greece, then referred to as "Russian hail", and later as "ghost rockets", because it was thought that these mysterious objects were possibly Russian tests of captured German V1 or V2 rockets. Although most were thought to be natural phenomena like meteors, over 200 were tracked on radar and deemed to be "real physical objects" by the Swedish military. In a 1948 top secret document, the Swedish military told the USAF Europe in 1948 that some of their investigators believed them to be extraterrestrial in origin.

the Kenneth Arnold sightings

Main article: Kenneth Arnold#June 24, 1947 UFO sighting
This shows the report Kenneth Arnold filed in 1947 about his UFO sighting.

The post World War II UFO phase in the United States began with a famous sighting by American businessman Kenneth Arnold on June 24, 1947 while flying his private plane near Mount Rainier, Washington. He reported seeing nine brilliantly bright objects flying across the face of Rainier.

Although there were other 1947 U.S. sightings of similar objects that preceded this, it was Arnold's sighting that first received significant media attention and captured the public's imagination. Arnold described what he saw as being "flat like a pie pan", "shaped like saucers and were so thin I could barely see them… ", "half-moon shaped, oval in front and convex in the rear. … they looked like a big flat disk" , and flew "like a saucer would if you skipped it across the water". (One of the objects, however, he would describe later as crescent-shaped, as shown in illustration at left.) Arnold’s descriptions were widely reported and within a few days gave rise to the terms flying saucer and flying disk. Arnold’s sighting was followed in the next few weeks by hundreds of other reported sightings, mostly in the U.S., but in other countries as well.

After reports of the Arnold sighting hit the media, other cases began to be reported in increasing numbers. In one instance a United Airlines crew sighting of nine more disc-like objects over Idaho on the evening of July 4. At the time, this sighting was even more widely reported than Arnold’s and lent considerable credence to Arnold’s report.

American UFO researcher Ted Bloecher, in his comprehensive review of newspaper reports (including cases that preceded Arnold's), found a sudden surge upwards in sightings on July 4, peaking on July 6–8. Bloecher noted that for the next few days most American newspapers were filled with front-page stories of the new "flying saucers" or "flying discs". Reports began to rapidly tail off after July 8, when officials began issuing press statements on the Roswell UFO incident, in which they explained debris found on the ground by a rancher as being that of a weather balloon.

Over several years in the 1960s, Bloecher (aided by physicist James E. McDonald) discovered 853 flying disc sightings that year from 140 newspapers from Canada, Washington D.C, and every U.S. state except Montana.

investigations

UFOs have been subject to investigations over the years that vary widely in scope and scientific rigor. Governments or independent academics in the United States, Canada, the United Kingdom, Japan, Peru, France, Belgium, Sweden, Brazil, Chile, Uruguay, Mexico, Spain, and the Soviet Union are known to have investigated UFO reports at various times.

Among the best known government studies are the ghost rockets investigation by the Swedish military (1946–1947), Project Blue Book, previously Project Sign and Project Grudge, conducted by the United States Air Force from 1947 until 1969, the secret U.S. Army/Air Force Project Twinkle investigation into green fireballs (1948–1951), the secret USAF Project Blue Book Special Report #14 by the Battelle Memorial Institute, and Brazilian Air Force Operation Saucer (1977). France has had on ongoing investigation (GEPAN/SEPRA/GEIPAN) within its space agency CNES since 1977, as has Uruguay since 1989.

A public research effort conducted by the Condon Committee for the USAF, which arrived at a negative conclusion in 1968, marked the end of the US government's official investigation of UFOs, though documents indicate various government intelligence agencies continue unofficially to investigate or monitor the situation.

Jacques Vallée, a scientist and prominent UFO researcher, has argued that most UFO research is scientifically deficient, including many government studies such as Project Blue Book, and that mythology and cultism are frequently associated with the phenomenon. Vallée states that self-styled scientists often fill the vacuum left by the lack of attention paid to the UFO phenomenon by official science, but also notes that several hundred professional scientists continue to study UFOs in private, what he terms the "invisible college". He also argues that much could be learned from rigorous scientific study, but that little such work has been done.

There has been little mainstream scientific study of UFOs, and the topic has received little serious attention or support in mainstream scientific literature. Official studies ended in the U.S. in December 1969, subsequent to the statement by Edward Condon that the study of UFOs probably could not be justified in the expectation that science would be advanced. The Condon report and these conclusions were endorsed by the National Academy of Scientists, of which Condon was a member. However, a scientific review by the UFO subcommittee of the AIAA disagreed with Condon's conclusion, noting that at least 30% of the cases studied remained unexplained, and that scientific benefit might be gained by continued study.

It has been claimed that all UFO cases are anecdotal and that all can be explained as prosaic natural phenomena. On the other hand, it has been argued that there is limited awareness among scientists of observational data, other than what is reported in the popular press.

Controversy has surrounded the Condon report, both before and after it was released. It has been claimed that the report was "harshly criticized by numerous scientists, particularly at the powerful AIAA … [who] recommended moderate, but continuous scientific work on UFOs". In an address made to the AAAS, James E. McDonald stated that he believed science had failed to mount adequate studies of the problem, criticizing the Condon report and prior studies by the US Air Force for being scientifically deficient. He also questioned the basis for Condon's conclusions and argued that the reports of UFOs have been "laughed out of scientific court." J. Allen Hynek, an astronomer whose position as USAF consultant from 1948 made him perhaps the most knowledgeable scientist connected with the subject, sharply criticized the report of the Condon Committee and later wrote two nontechnical books that set forth the case for investigating seemingly baffling UFO reports.

No official government investigation has ever publicly concluded that UFOs are indisputably real, physical objects, extraterrestrial in origin, or of concern to national defense. These same negative conclusions also have been found in studies that were highly classified for many years, such as the UK's Flying Saucer Working Party, Project Condign, the US CIA-sponsored Robertson Panel, the US military investigation into the green fireballs from 1948 to 1951, and the Battelle Memorial Institute study for the USAF from 1952 to 1955 (Project Blue Book Special Report #14).

However, the initially classified USAF Regulation 200-2, first issued in 1953 after the Robertson Panel, which first defined UFOs and how information was to be collected, stated explicitly that the two reasons for studying the unexplained cases were for national security reasons and for possible technical aspects involved, implying physical reality and concern about national defense, but without opinion as to origins. (For example, such information would also be considered important if UFOs had a foreign or domestic origin.) The first two known classified USAF studies in 1947 also concluded real physical aircraft were involved, but gave no opinion as to origins. (See American investigations immediately below) These early studies led to the creation of the USAF's Project Sign at the end of 1947, the first semi-public USAF study.

Project Sign in 1948 wrote a highly classified opinion (see Estimate of the Situation) that the best UFO reports probably had an extraterrestrial explanation, as did the private but high-level French COMETA study of 1999. A top secret Swedish military opinion given to the USAF in 1948 stated that some of their analysts believed the 1946 ghost rockets and later flying saucers had extraterrestrial origins. (see Ghost rockets for document). In 1954, German rocket scientist Hermann Oberth revealed an internal West German government investigation, which he headed, that arrived at an extraterrestrial conclusion, but this study was never made public. Classified, internal reports by the Canadian Project Magnet in 1952 and 1953 also assigned high probability to extraterrestrial origins. Publicly, however, Project Magnet, nor later Canadian defense studies, ever stated such a conclusion.

Another highly classified U.S. study was conducted by the CIA's Office of Scientific Investigation (OS/I) in the latter half of 1952 after being directed to do so by the National Security Council (NSC). They concluded UFOs were real physical objects of potential threat to national security. One OS/I memo to the CIA Director (DCI) in December read, "...the reports of incidents convince us that there is something going on that must have immediate attention... Sightings of unexplained objects at great altitudes and traveling at high speeds in the vicinity of major U.S. defense installations are of such a nature that they are not attributable to natural phenomena or any known types of aerial vehicles." The matter was considered so urgent, that OS/I drafted a memorandum from the DCI to the NSC proposing that the NSC establish an investigation of UFOs as a priority project throughout the intelligence and the defense research and development community. They also urged the DCI to establish an external research project of top-level scientists to study the problem of UFOs, now known as the Robertson Panel, to further analyze the matter. The OS/I investigation was called off after the Robertson Panel's negative conclusions in January 1953.

Some public government conclusions have indicated physical reality but stopped short of concluding extraterrestrial origins, though not dismissing the possibility. Examples are the Belgian military investigation into large triangles over their airspace in 1989–1991 and the recent 2009 Uruguay Air Force study conclusion (see below).

Some private studies have been neutral in their conclusions, but argued the inexplicable core cases called for continued scientific study. Examples are the Sturrock Panel study of 1998 and the 1970 AIAA review of the Condon Report.

astronomer reports

The Air Force's Project Blue Book files indicate that approximately 1 % of all unknown reports came from amateur and professional astronomers or other users of telescopes (such as missile trackers or surveyors). In 1952, astronomer J. Allen Hynek, then a consultant to Blue Book, conducted a small survey of 45 fellow professional astronomers. Five reported UFO sightings (about 11%). In the 1970s, astrophysicist Peter A. Sturrock conducted two large surveys of the American Institute of Aeronautics and Astronautics and American Astronomical Society. About 5 % of the members polled indicated that they had had UFO sightings.

Astronomer Clyde Tombaugh, who admitted to six UFO sightings, including three green fireballs, supported the Extraterrestrial hypothesis (ETH) for UFOs and stated he thought scientists who dismissed it without study were being "unscientific." Another astronomer was Lincoln LaPaz, who had headed the Air Force's investigation into the green fireballs and other UFO phenomena in New Mexico. LaPaz reported two personal sightings, one of a green fireball, the other of an anomalous disc-like object. (Both Tombaugh and LaPaz were part of Hynek's 1952 survey.) Hynek himself took two photos through the window of a commercial airliner of a disc-like object that seemed to pace his aircraft. Even later UFO debunker Donald Menzel filed a UFO report in 1949.

In 1980, a survey of 1800 members of various amateur astronomer associations by Gert Helb and Hynek for the Center for UFO Studies (CUFOS) found that 24 % responded "yes" to the question "Have you ever observed an object which resisted your most exhaustive efforts at identification?"

identification of ufos

Studies show that after careful investigation, the majority of UFOs can be identified as ordinary objects or phenomena (see Identification studies of UFOs). The most commonly found identified sources of UFO reports are:

* Astronomical objects (bright stars, planets, meteors, re-entering man-made spacecraft, artificial satellites, and the moon)
* Aircraft (Aerial advertising and other aircraft, missile launches)
* Balloons (weather balloons, prank balloons, large research balloons)

Much less common sources of UFO reports include:

* Other atmospheric objects and phenomena (birds, unusual clouds, kites, flares)
* Light phenomena (mirages, Fata Morgana, moon dogs, searchlights and other ground lights, etc.)
* Hoaxes

A 1952–1955 study by the Battelle Memorial Institute for the US Air Force included these categories as well as a "psychological" one. However, the scientific analysts were unable to come up with prosaic explanations for 21.5 % of the 3200 cases they examined and 33 % of what were considered the best cases remained unexplained, double the number of the worst cases. (See full statistical breakdown in Identification studies of UFOs). Of the 69 % identifieds, 38 % were deemed definitely explained while 31 % were thought to be "questionable." About 9 % of the cases were considered to have insufficient information to make a determination.

The official French government UFO investigation (GEPAN/SEPRA/GEIPAN), run within the French space agency CNES between 1977 and 2004, scientifically investigated about 6000 cases and found that 13.5 % defied any rational explanation, 46 % were deemed definitely or likely identifiable, while 41 % lacked sufficient information for classification.

An individual 1979 study by CUFOS researcher Allan Hendry found, as did other investigations, that only a small percentage of cases he investigated were hoaxes (<1 %) and that most sightings were actually honest misidentifications of prosaic phenomena. Hendry attributed most of these to inexperience or misperception. However, Hendry's figure for unidentified cases was considerably lower than many other UFO studies such as Project Blue Book or the Condon Report that have found rates of unidentified cases ranging from 6 % to 30 %. Hendry found that 88.6 % of the cases he studied had a clear prosaic explanation, and he discarded a further 2.8 % due to unreliable or contradictory witnesses or insufficient information. The remaining 8.6 % of reports could not definitively be explained by prosaic phenomena, although he felt that a further 7.1 % could possibly be explained, leaving only the very best 1.5 % without plausible explanation.

ufo hypotheses

To account for unsolved UFO cases, several hypotheses have been proposed.

* The Extraterrestrial hypothesis (ETH), defined by Edward U. Condon in the 1968 Condon Report as "The idea that some UFOs may be spacecraft sent to Earth from another civilization, or on a planet associated with a more distant star", further attributing the popularity of the idea to Donald Keyhoe's UFO book from 1950,[63] though the idea clearly predated Keyhoe, appearing in newspapers and various government documents (see immediately below). This is probably the most popular theory among Ufologists. Some private or governmental studies, some secret, have concluded in favor of the Extraterrestrial hypothesis (ETH), or have had members who disagreed with official conclusions against the conclusion by committees and agencies to which they belonged.
* The Interdimensional hypothesis, that UFOs are objects crossing over from other dimensions or parallel universe, popularly proposed by Jacques Vallée, though also predating him.
* The paranormal/occult hypothesis; A variant of the Interdimensional Hypothesis, invoked to explain so-called paranormal aspects sometimes associated with UFO reports
* The psychosocial hypothesis, that what people report as UFO experiences is the result of psychological misperception mechanisms and is strongly influenced by popular culture.
* That UFOs represent poorly understood or still unknown natural phenomena, such as ball lightning or sprites.
* The Earthquake lights/Tectonic Strain hypothesis: UFOs are caused by strains in Earth's crust near earthquake faults, which can also supposedly induce hallucinations.
* That UFOs are military flying saucers; top secret or experimental aircraft unfamiliar to most people.

physical evidence

Besides visual sightings, reports sometimes include claims of indirect and direct physical evidence, including cases studied by the military and various government agencies of different countries (such as Project Blue Book, the Condon Committee, the French GEPAN/SEPRA, and Uruguay's current Air Force study).

Reported physical evidence cases have also been studied by various private scientist and engineers. For example, researcher Ted Phillips, a protege of J. Allen Hynek at CUFOS, has studied 3200 so-called UFO trace evidence cases typically associated with alleged landings or close interactions. Such traces include such things as tree and foliage damage, vehicle damage, electromagnetic effects, radiation, various residues, footprints, and soil depression, burning, and desiccation. Although many such cases have dubious provenance, a number have been well-studied and authenticated by government studies, such as the 1964 Lonnie Zamora Socorro, N.M. case, the 1967 Canadian Falcon Lake Incident, and the 1981 French Trans-en-Provence Case. Phillips has compiled a list of some of the best-quality authenticated cases.

A comprehensive scientific review of physical evidence cases was carried out by the 1998 Sturrock UFO panel, with specific examples of many of the categories listed below.

* Radar contact and tracking, sometimes from multiple sites. These may involve trained military personnel and control tower operators, simultaneous visual sightings, and aircraft intercepts. One such recent example were the mass sightings of large, silent, low-flying black triangles in 1989 and 1990 over Belgium, tracked by multiple NATO radar and jet interceptors, and investigated by Belgium's military (included photographic evidence).Another famous case from 1986 was the JAL 1628 case over Alaska investigated by the FAA.
* Photographic evidence, including still photos, movie film, and video.
* Claims of physical trace of landing UFOs, including ground impressions, burned and/or desiccated soil, burned and broken foliage, magnetic anomalies[specify], increased radiation levels, and metallic traces. See, e. g. Height 611 UFO Incident or the 1964 Lonnie Zamora's Socorro, New Mexico encounter of the USAF Project Blue Book cases). A well-known example from December 1980 was the USAF Rendlesham Forest Incident in England. Another less than two weeks later, in January 1981, occurred in Trans-en-Provence and was investigated by GEPAN, then France's official government UFO-investigation agency. Project Blue Book head Edward J. Ruppelt described a classic 1952 CE2 case involving a patch of charred grass roots.
* Physiological effects on people and animals including temporary paralysis, skin burns and rashes, corneal burns, and symptoms superficially resembling radiation poisoning, such as the Cash-Landrum incident in 1980. One such case dates back to 1886, a Venezuelan incident reported in Scientific American magazine.
* Animal/cattle mutilation cases, that some feel are also part of the UFO phenomenon.
* Biological effects on plants such as increased or decreased growth, germination effects on seeds, and blown-out stem nodes (usually associated with physical trace cases or crop circles)
* Electromagnetic interference (EM) effects. A famous 1976 military case over Tehran, recorded in CIA and DIA classified documents, resulted in communication losses in multiple aircraft and weapons system failure in an F-4 Phantom II jet interceptor as it was about to fire a missile on one of the UFOs. This was also a radar/visual case.
* Remote radiation detection, some noted in FBI and CIA documents occurring over government nuclear installations at Los Alamos National Laboratory and Oak Ridge National Laboratory in 1950, also reported by Project Blue Book director Ed Ruppelt in his book.
* Actual hard physical evidence cases, such as 1957, Ubatuba, Brazil, magnesium fragments analyzed by the Brazilian government and in the Condon Report and by others. The 1964 Socorro/Lonnie Zamora incident also left metal traces, analyzed by NASA. A more recent example involves "the Bob White object" a tear drop shaped object recovered by Bob White and was featured in the TV show UFO hunters
* Angel hair and angel grass, possibly explained in some cases as nests from ballooning spiders or chaff.

reverse engineering

Attempts have been made to reverse engineer the possible physics behind UFOs through analysis of both eyewitness reports and the physical evidence, on the assumption that they are powered vehicles. Examples are former NASA and nuclear engineer James McCampbell in his book Ufology, NACA/NASA engineer Paul R. Hill in his book Unconventional Flying Objects, and German rocketry pioneer Hermann Oberth. Among subjects tackled by McCampbell, Hill, and Oberth was the question of how UFOs can fly at supersonic speeds without creating a sonic boom. McCampbell's proposed solution is microwave plasma parting the air in front of the craft. In contrast, Hill and Oberth believed UFOs utilize an as yet unknown anti-gravity field to accomplish the same thing as well as provide propulsion and protection of occupants from the effects of high acceleration.

ufo categorization

Some ufologists recommend that observations be classified according to the features of the phenomenon or object that are reported or recorded. Typical categories include:

* Saucer, toy-top, or disk-shaped "craft" without visible or audible propulsion. (day and night)
* Large triangular "craft" or triangular light pattern, usually reported at night.
* Cigar-shaped "craft" with lighted windows (Meteor fireballs are sometimes reported this way, but are very different phenomena).
* Other: chevrons, (equilateral) triangles, crescent, boomerangs, spheres (usually reported to be shining, glowing at night), domes, diamonds, shapeless black masses, eggs, pyramids and cylinders, classic "lights".

Popular UFO classification systems include the Hynek system, created by J. Allen Hynek, and the Vallée system, created by Jacques Vallée.

Hynek's system involves dividing the sighted object by appearance, subdivided further into the type of "close encounter" (a term from which the film director Steven Spielberg derived the title of his UFO movie, "Close Encounters of the Third Kind").

Jacques Vallée's system classifies UFOs into five broad types, each with from three to five subtypes that vary according to type.

conspiracy theories

UFOs are sometimes an element of elaborate conspiracy theories in which governments are said to be intentionally covering up the existence of aliens, or sometimes collaborating with them. There are many versions of this story; some are exclusive, while others overlap with various other conspiracy theories.

In the U.S., an opinion poll conducted in 1997 suggested that 80 % of Americans believed the U.S. government was withholding such information. Various notables have also expressed such views. Some examples are astronauts Gordon Cooper and Edgar Mitchell, Senator Barry Goldwater, Vice Admiral Roscoe H. Hillenkoetter (the first CIA director), Lord Hill-Norton (former British Chief of Defense Staff and NATO head), the 1999 high-level French COMETA report by various French generals and aerospace experts, and Yves Sillard (former director of the French space agency CNES, new director of French UFO research organization GEIPAN).

It has also been suggested by a few paranormal authors that all or most human technology and culture is based on extraterrestrial contact. See also ancient astronauts.